Caveolin-1 Expression in Odontogenic Cysts and Ameloblastomas Ameloblastom ve Odontojenik Kistlerde Caveolin-1 Ekspresyonu

Odontogenic cysts and tumors originate from remnants of odontogenic epithelium and have a wide spectrum of histopathologic and clinical characteristics, ranging from benign non-invasive to locally invasive or malignant lesions. Histopathologic similarities between these lesions may challenge the correct diagnosis, especially in small size specimens, and may also lead to unnecessary broad surgery (15). Recently, immunohistochemistry (IHC) has been employed to differentiate various lesions or predict their biologic behavior by using proper markers (6). For example, some cytokeratins have been investigated and found to be suitable for differentiating odontogenic keratocysts from other odontogenic cysts (7). It is also stated that calretinin is a marker for stellate reticulum-like cells of ameloblastoma and can be used to distinguish this tumor from other odontogenic tumors (8).